References by Therapeutic Areas

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Therapeutic Area

Reference

Study

Clinical Evidence

1) Preclinical

Amino acids in cancer and cachexia: an integrated view

Essential amino acid formulations to prevent mitochondrial dysfunction and oxidative stress

Experimental evidence on the efficacy of two new metabolic modulators on mitochondrial biogenesis and function in mouse cardiomyocytes

Targeting multiple mitochondrial processes by a metabolic modulator prevents sarcopenia and cognitive decline in SAMP8 mice

2) Motor rehabilitation:
Metabolic support in rehabilitation, strengthening the effectiveness of physiotherapy, pain reduction in physiotherapy

Effects of a new multicomponent nutritional supplement on muscle mass and physical performance in adult and old patients recovered from Covid-19: a pilot observational case–control study

Comparison of protein- or amino acid-based supplements in the rehabilitation of men with severe obesity: a randomized controlled pilot study.

3) Nephrology:
Reduction of malnutrition/sarcopenia, reduction of anemia, increase of albuminemia in patients in hemodialysis

Effects of a novel amino acid formula on nutritional and metabolic status, anemia and myocardial function in thrice-weekly hemodialysis patients: results of a six-month randomized double-blind placebo-controlled pilot study

Effects of a metabolic mixture on gut inflammation and permeability in elderly patients with chronic kidney disease: a proof-of-concept study

Altered amino acid metabolism in patients with cardiorenal syndrome type 2: is it a problem for protein and exercise prescriptions?

Differences and effects of metabolic fate of individual amino acid loss in high-efficiency hemodialysis and hemodiafiltration

Differences in amino acid loss between high-efficiency hemodialysis and postdilution and predilution hemodiafiltration using high convection volume exchange – A new metabolic scenario? A pilot study

4) Oncology:
Increased albumin, decreased ROS, increased weight in patients with cachexia

Peripheral blood lymphocyte percentage may predict chemotolerance and survival in patients with advanced pancreatic cancer. association between adaptive immunity and nutritional state

5) Alzheimer:

Is the Brain Undernourished in Alzheimer’s Disease?

Mini nutritional assessment may identify a dual pattern of perturbed plasma amino acids in patients with Alzheimer’s disease: a window to metabolic and physical rehabilitation?

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